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Trial Details

  • Trial statusCompleted
  • Study email contactVANISH@imperial.ac.uk
  • Chief InvestigatorDr Anthony Gordon
  • Project managerNeeraja Thirunavukkarasu
  • SponsorImperial College London
  • ISRCTN numberISRCTN20769191
  • PhaseIV

Vasopressin vs Noradrenaline as Initial therapy in Septic Shock

Design and Objective

The primary objectives are: 1. To test if vasopressin reduces renal dysfunction compared to noradrenaline when used as the initial vasopressor in the management of adult patients who have septic shock. 2. To test if there is an interaction between vasopressin and corticosteroids when used in the management of septic shock?

Key inclusion criteria

- Hypotension despite adequate intravenous fluid resuscitation AND two of the following: - Fever (>38 C) or hypothermia (<36 C) - Tachycardia (heart rate >90 bpm) - Tachypnoea (respiratory rate >20 breaths per min or PaCO2 <4.3 kPa) or on mechanical ventilation - Abnormal leukocyte count (>12,000/<4000 cells mm3)

Study Disclaimer Statement