ICTUImperial Clinical Trials Unit

Welcome to Imperial Clinical Trials Unit (ICTU)

This website is intended for people who are considering taking part in clinical trials and would like to find out more about what’s involved, why clinical trials are important and what the benefits of taking part in trials are. You can also find out about current clinical trials going on in ICTU and how to get involved.

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Trial Details

  • Trial statusAnalysis
  • Study email contactREI-EXCISE@imperial.ac.uk
  • Chief InvestigatorProf Zoltan Takats and Mr Daniel Leff
  • Project managerDr Ambreen Ashraf
  • SponsorImperial College London
  • Phasen/a

Rapid Evaporative Ionisation Mass Spectrometry for Examination of Circumferential Surgical Excision Margins

Design and Objective

This study will help determine if the iKnife (intelligent knife) can detect normal breast tissue or cancerous tissue. To answer this question, smoke (which is a by-product of surgery) will be collected and analysed by a mass spectrometer. Patients who are undergoing surgery to remove part of their breast tissues which are known to be either cancerous or pre-cancerous will be invited to participate in this study.

Key inclusion criteria

Patients undergoing breast conserving surgery (BCS) for invasive or non-invasive breast cancer. Inclusion Criteria: • Minimum age 18 (there is no upper age limit) • BCS for ductal carcinoma in situ (B5a) • BCS for invasive ductal carcinoma (B5b) • BCS for invasive lobular carcinoma (B5b) • B3 lesions undergoing surgical excision

Study Disclaimer Statement

Funded by Cancer Research UK