MOTION
Trial Details
- Trial statusFollowup
- Study email contactMOTION@imperial.ac.uk
- Chief InvestigatorDr Parind Patel
- Project managerAisha Anjum
- SponsorImperial College Academic Health Science Centre
- ISRCTN numberISRCTN75305839
- PhaseIV
Methylnaltrexone for the Treatment of Opioid Induced Constipation & Gastro-Intestinal Stasis in Intensive Care Patients
Design and Objective
The primary objective is to assess the efficacy of Methylnaltrexone in producing laxation in ICU patients sedated with opioid infusions.
Key inclusion criteria
- Male/female ≥ 18 years of age - In ICU, sedated with opioids and on invasive ventilation - Requiring opioids for at least a further 24 hours - Constipated (not opened bowels for at least 48 hours in ICU) - On nasogastric tube feeds - Enteral access for administration of medications - Patient weight of 38-114kg