ICTUImperial Clinical Trials Unit

Welcome to Imperial Clinical Trials Unit (ICTU)

This website is intended for people who are considering taking part in clinical trials and would like to find out more about what’s involved, why clinical trials are important and what the benefits of taking part in trials are. You can also find out about current clinical trials going on in ICTU and how to get involved.

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Trial Details

  • Trial statusCompleted
  • Study email contactMOTION@imperial.ac.uk
  • Chief InvestigatorDr Parind Patel
  • Project managerAisha Anjum
  • SponsorImperial College Academic Health Science Centre
  • ISRCTN numberISRCTN75305839
  • PhaseIV

Methylnaltrexone for the Treatment of Opioid Induced Constipation & Gastro-Intestinal Stasis in Intensive Care Patients

Design and Objective

The primary objective is to assess the efficacy of Methylnaltrexone in producing laxation in ICU patients sedated with opioid infusions.

Key inclusion criteria

- Male/female ≥ 18 years of age - In ICU, sedated with opioids and on invasive ventilation - Requiring opioids for at least a further 24 hours - Constipated (not opened bowels for at least 48 hours in ICU) - On nasogastric tube feeds - Enteral access for administration of medications - Patient weight of 38-114kg

Study Disclaimer Statement