ICTUImperial Clinical Trials Unit

Welcome to Imperial Clinical Trials Unit (ICTU)

This website is intended for people who are considering taking part in clinical trials and would like to find out more about what’s involved, why clinical trials are important and what the benefits of taking part in trials are. You can also find out about current clinical trials going on in ICTU and how to get involved.

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Trial Details

Investigation of the safety and feasibility of AAV1/SERCA2a gene transfer in patients with chronic heart failure and a left ventricular assist device

Design and Objective

This study is being performed to understand if gene transfer to increase SERCA2a protein may help patients with heart failure. Researchers have found that failing hearts have lost a protein called SERCA2a, which controls the strength of the heart muscle. Increasing the levels of this protein improves the contraction and relaxation of the heart. The purpose of this research study is to understand more about SERCA gene delivery.

Key inclusion criteria

1. Patients that have had a left ventricular assist device (LVAD) implanted for chronic heart failure, where chronic heart failure is defined as at least 6 months 2. Patients are clinically stable in the opinion of the clinical team looking after the patient 3. Written informed consent

Study Disclaimer Statement