ICTUImperial Clinical Trials Unit

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Trial Details

  • Trial statusClosed
  • Study email contactazaleatrial@imperial.ac.uk
  • Chief InvestigatorProfessor Sebastian Johnston
  • Project managern/a - study complete
  • SponsorImperial College, London
  • Phase4

A Randomised, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Oral Azithromycin (500 Mg OD) as a Supplement to Standard Care for Adult Patients with Acute Exacerbations of Asthma

Design and Objective

Acute attacks (exacerbations) of asthma are common and cause a great deal of suffering and occasionally death. Current treatments for asthma attacks are not very effective and new and better treatments are needed. We will study whether an antibiotic called Azithromycin is effective at reducing patient symptoms after an asthma attack compared to placebo ('dummy treatment'). We will also study why it may be effective.

Key inclusion criteria

Adults 18 and over of either sex with a documented history of asthma for >6 consecutive months, with a PEF or FEV1 less than 80% of predicted normal and presenting with 48 hours (of initial presentation to medical care) with an acute deterioration in asthma control and requiring a course of oral steroids.

Study Disclaimer Statement